Elevated Tyrosine Hydroxylase mRNA Levels in the Adrenal Medulla of Spontaneously Hypertensive Rats

The Japanese Journal of Pharmacology

Toshio Kumai¹  Minoru Watanabe¹  Masami Tanaka¹  Shinichi Kobayashi¹ 

[1] Department of Pharmacology, St. Marianna University School of Medicine

关键词: Tyrosine hydroxylase mRNA;    Adrenal medulla;    Spontaneously hypertensive rat;   

DOI  :  10.1254/jjp.65.367

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(13)Cited-By(13)We investigated the expression of tyrosine hydroxylase (TH) mRNA and its activity in the adrenal medulla of spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY). The TH mRNA levels were determined by Northern blot and dot blot analyses. The TH activity and the expression of TH mRNA in the adrenal medulla of SHR were significantly higher than those of WKY (P <0.01). These results suggested that the hypertension of SHR may be related to the high activity of TH due to the high level of TH mRNA, which increases epinephrine and norepinephrine levels in the adrenal medulla.

【 授权许可】

Unknown