A systems approach identifies co-signaling molecules of early growth response 1 transcription factor in immobilization stress

BMC Systems Biology

Esther L Sabban⁴  Athanasios G Papavassiliou²  Xiaoping Liu³  Andrej Tillinger⁴  Nikolaos A Papanikolaou¹ 

[1] Laboratory of Biological Chemistry, Department of Medicine, Aristotle University of Thessaloniki, Thessaloniki, 54124, Hellas (Greece);Department of Biological Chemistry, Medical School, University of Athens, 75 M. Asias Street, Athens, 11527, Hellas (Greece);Current Address: Clyde and Helen Wu Center of Molecular Cardiology, Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, New York 10032, NY, USA;Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla 10595, NY, USA

关键词: Stress;    Networks;    Prlh1;    Stat3;    Egr1;    Adrenal medulla;   

Others  :  1127080
DOI  :  10.1186/s12918-014-0100-8

 received in 2013-05-22, accepted in 2014-08-13,  发布年份 2014

【 摘 要 】

Background

Adaptation to stress is critical for survival. The adrenal medulla, the major source of epinephrine, plays an important role in the development of the hyperadenergic state and increased risk for stress associated disorders, such as hypertension and myocardial infarction. The transcription factor Egr1 plays a central role in acute and repeated stress, however the complexity of the response suggests that other transcription factor pathways might be playing equally important roles during acute and repeated stress. Therefore, we sought to discover such factors by applying a systems approach.

Results

Using microarrays and network analysis we show here for the first time that the transcription factor signal transducer and activator of transcription 3 (Stat3) gene is activated in acute stress whereas the prolactin releasing hormone (Prlh11) and chromogranin B (Chgb) genes are induced in repeated immobilization stress and that along with Egr1 may be critical mediators of the stress response.

Conclusions

Our results suggest possible involvement of Stat3 and Prlh1/Chgb up-regulation in the transition from short to repeated stress activation.

【 授权许可】

   
2014 Papanikolaou et al.; licensee BioMed Central

【 图 表 】

Figure 1.

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