Class-Specific Binding of Two Aminoacyl-tRNA Synthetases to Annexin, a Ca2+- and Phospholipid-Binding Protein

Cell Structure and Function

Akio Nakamura¹  Kazuhiro Kohama¹  Michito Hirakata²  Tomohiro Shirakawa³  Satoshi Ogihara³ 

[1] Department of Molecular and Cellular Pharmacology, Faculty of Medicine, Gunma University Graduate School of Medicine;Department of Internal Medicine, Keio University School of Medicine;Graduate School of Science, Biological Science, Osaka University

关键词: annexin;    aminoacyl-tRNA synthetase;    Physarum polycephalum;    myositis;   

DOI  :  10.1247/csf.29.159

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(13)Cited-By(2)Annexins are a family of Ca2+/phospholipid-binding proteins that have diverse functions. To understand the function of annexin in Physarum polycephalum, we searched for its binding proteins. Here we demonstrate the presence of two novel annexin-binding proteins. The homology search of partial amino acid sequences of these two proteins identified them as aminoacyl-tRNA synthetases (ARSs). Furthermore, antibody against aminoacyl-tRNA synthetases cross-reacted with one of two proteins. Our results imply the interaction between intracellular membrane dynamics and protein translation system, and may give a clue to understand the mechanism of some myositis diseases, which have been known to produce autoantibodies against ARSs.

【 授权许可】

Unknown