Histone gene expression in Physarum polycephalum 2

FEBS Letters

Kelly, P.M.¹  Schofield, P.N.¹  Walker, I.O.¹ 

[1] Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England

关键词: Histone synthesis;    DNA replication;    Physarum polycephalum;   

DOI  :  10.1016/0014-5793(83)80734-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The addition of hydroxyurea to synchronously growing macroplasmodia of the slime mould, Physarum polycephalum, inhibited DNA synthesis by up to 90%. Histone protein synthesis was inhibited to the same extent. The synthesis of other nuclear proteins was not inhibited even though total RNA synthesis was inhibited. The results suggest that histone synthesis and DNA replication are tightly coupled.

【 授权许可】

Unknown