Facile and Efficient Synthesis of [18F]Fluoromisonidazole Using Novel 2-Nitroimidazole Derivatives

Journal of the Brazilian Chemical Society

Chonbuk National University, Jeonbuk, South Korea¹  Jung, Yongju¹  Kwon, Young-Do¹  Korea University of Technology and Education, Cheonan, South Korea¹  Sohn, Myung-Hee¹  Kim, Hee-Kwon¹  Lim, Seok Tae¹ 

关键词:  [18F]FMISO;    radiosynthesis;    fluorine-18;    one-pot synthesis;    positron emission tomography;   

DOI  :  10.5935/0103-5053.20160010

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

[18F]Fluoromisonidazole ([18F]FMISO) is a hypoxia imaging marker utilized in positron emission tomography. Novel FMISO precursors were prepared from a commercially available material, and several reaction factors that affect synthesis of [18F]FMISO were examined to achieve a higher fluorination yield. [18F]FMISO was obtained from radiosynthesis, followed by the hydrolysis of protecting groups with HCl. New 2-nitroimidazole precursor showed a higher [18F]fluorination and a higher synthetic yield. This result provided alternative guidelines for the preparation of hypoxia imaging marker.

【 授权许可】

Unknown