A systematic investigation of PET Radionuclide Specific Activity on Miniaturization of Radiochemistry

Jeanne M Link, PhD

关键词: PET radiochemistry;    carbon-11;    fluorine-18;    specific activity;   

DOI  :  10.2172/1036014
RP-ID  :  DOE ER64668-2
PID  :  OSTI ID: 1036014
Others  :  Other: 014615
Others  :  61-7621

学科分类：化学（综合）

美国|英语

来源: SciTech Connect

【 摘 要 】

The PET radionuclides, 18F and 11C consist of very high radiation to mass amounts and should be easily adapted to new technologies such as chip chemistry with nanofluidics. However, environmental contamination with nonradioactive fluorine, carbon and other trace contaminants add sufficient mass, micrograms to milligrams, to prevent adapting PET radiochemistry to the nanochip technologies. In addition, the large volumes of material required for beam irradiation make it necessary to also remove the 18F and 11C from their chemical matrices. These steps add contaminants. The work described in this report was a systematic investigation of sources of these contaminants and methods to reduce these contaminants and the reaction volumes for radiochemical synthesis. Several methods were found to lower the contaminants and matrices to within a factor of 2 to 100 of those needed to fully implement chip technology but further improvements are needed.