Design and Optimization of Coin-Shaped Microreactor Chips for PET Radiopharmaceutical Synthesis

Journal of Nuclear Medicine

Hartmuth C. Kolb¹  Arkadij M. Elizarov¹  Jenny Shu¹  R. Michael van Dam¹  Antoine Daridon¹  Henry C. Padgett¹  James R. Heath¹  Jiang Huang¹  David Stout¹  Young Shik Shin¹ 

关键词: radiosynthesis;    microfluidics;    PET;    ¹⁸F-FDG;    instrumentation;   

DOI  :  10.2967/jnumed.109.065946

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

An integrated elastomeric microfluidic device, with a footprint the size of a postage stamp, has been designed and optimized for multistep radiosynthesis of PET tracers. Methods: The unique architecture of the device is centered around a 5-μL coin-shaped reactor, which yields reaction efficiency and speed from a combination of high reagent concentration, pressurized reactions, and rapid heat and mass transfer. Its novel features facilitate mixing, solvent exchange, and product collection. New mixing mechanisms assisted by vacuum, pressure, and chemical reactions are exploited. Results: The architecture of the reported reactor is the first that has allowed batch-mode microfluidic devices to produce radiopharmaceuticals of sufficient quality and quantity to be validated by in vivo imaging. Conclusion: The reactor has the potential to produce multiple human doses of 18F-FDG; the most impact, however, is expected in the synthesis of PET radiopharmaceuticals that can be made only with low yields by currently available equipment.

【 授权许可】

Unknown