LaCl3.7H2O: An efficient catalyst for the synthesis of phosphinates (Michaelis-Arbuzov reaction) under neat conditions and their potential antimicrobial activity

Journal of Chemical Sciences

Rasheed Syed²  Naga Raju Chamarthi1²  Subba Rao Devineni²  Madhava Golla²  Venkata Ramana Katla²  Naresh Kondapalli¹ 

[1] Department of Biochemistry, Sri Venkateswara University, Tirupati 517 502, India$$;Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, India$$

关键词: Michaelis-Arbuzov reaction;    neat reaction;    LaCl3.7H2O catalyst;    antimicrobial activity.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

An expeditious neat procedure was developed for the synthesis of a series of new methyl phenyl heterocyclic phosphinates (3a-l) through Michaelis-Arbuzov reaction by the reaction of various heterocyclic halides (Cl or Br) (1a-l) with dimethyl phenylphosphonite (2) under N2 atmosphere using a heterogeneous catalyst, LaCl3.7H2O. The advantages of the developed procedure are good yields (80-89%) of the products, less reaction time (2-3 h), avoiding toxic catalysts and harmful solvents and easy work-up procedure. Further, antimicrobial activity of the synthesized compounds was evaluated at different concentrations 50, 100 and 150 𝜇g/mL. Biological data revealed that compounds 3i, 3j and 3h, 3j exhibited potential antibacterial and antifungal activities, respectively, while the rest of the compounds showed moderate antimicrobial activity.

【 授权许可】

Unknown