Synthesis of aryl beta-N-acetylglucosaminedes modified at C-6 as potential antimicrovial agents

Química Nova

D'Angelis, Allison Fabiano¹  Alves, Ricardo José¹  Nunan, Elzíria de Aguiar¹  Figueiredo, Rute Cunha¹  Manfrini, Rozângela Magalhães¹  Martins, Gabriela Aires¹  Universidade Federal de Minas Gerais, Belo Horizonte, Brasil¹  Prado, Maria Auxiliadora Fontes¹  Souza Filho, José Dias de¹ 

关键词: N-acetylglucosamine derivatives;    antimicrobial activity.;   

DOI  :  10.1590/S0100-40422008000200026

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

We report herein the synthesis of aryl b-N-acetylglucosaminides containing azido, amino and acetamido groups at C-6 as potential antimicrobial agents. It was expected that these compounds could interfere with the biosynthesis and/or biotransformation of N-acetylglucosamine in fungi and bacteria. None of the compounds showed antimicrobial activity against bacteria (Bacillus subtilis, Micrococcus luteus, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa), filamentous fungus (Aspergillus niger) and yeasts (Saccharomyces cerevisae, Candida albicans and Candida tropicallis), at the concentration of 1 mg/mL in agar diffusion assay.

【 授权许可】

Unknown