Synthesis of aryl beta-N-acetylglucosaminedes modified at C-6 as potential antimicrovial agents

Quimica nova

D'Angelis, Allison Fabiano¹  Nunan, Elzíria de Aguiar¹  Alves, Ricardo José¹  Figueiredo, Rute Cunha¹  Manfrini, Rozângela Magalhães¹  Martins, Gabriela Aires¹  Prado, Maria Auxiliadora Fontes¹  Souza Filho, José Dias de¹ 

[1] Universidade Federal de Minas Gerais, Belo Horizonte, Brasil

关键词: N-acetylglucosamine derivatives;    antimicrobial activity.;   

DOI  :  10.1590/S0100-40422008000200026

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

We report herein the synthesis of aryl b-N-acetylglucosaminidescontaining azido, amino and acetamido groups at C-6 as potential antimicrobialagents. It was expected that these compounds could interfere with the biosynthesisand/or biotransformation of N-acetylglucosamine in fungi and bacteria.None of the compounds showed antimicrobial activity against bacteria (Bacillussubtilis, Micrococcus luteus, Staphylococcus aureus, Escherichiacoli and Pseudomonas aeruginosa), filamentous fungus (Aspergillusniger) and yeasts (Saccharomyces cerevisae, Candida albicansand Candida tropicallis), at the concentration of 1 mg/mL in agar diffusionassay.

【 授权许可】

CC BY