Síntese de beta-N-acetilglicosaminídeos de arila modificados em C-6 como potenciais agentes antimicrobianos

Química Nova

Rozângela Magalhães Manfrini¹  José Dias De Souza Filho¹  Rute Cunha Figueiredo²  Allison Fabiano D'angelis²  Maria Auxiliadora Fontes Prado²  Elzíria De Aguiar Nunan²  Gabriela Aires Martins²  Ricardo José Alves² 

[1] ,Universidade Federal de Minas Gerais Instituto de Ciências Exatas Departamento de QuímicaBelo Horizonte MG ,Brasil

关键词: N-acetylglucosamine derivatives;    antimicrobial activity;   

DOI  :  10.1590/S0100-40422008000200026

来源: SciELO

【 摘 要 】

We report herein the synthesis of aryl beta-N-acetylglucosaminides containing azido, amino and acetamido groups at C-6 as potential antimicrobial agents. It was expected that these compounds could interfere with the biosynthesis and/or biotransformation of N-acetylglucosamine in fungi and bacteria. None of the compounds showed antimicrobial activity against bacteria (Bacillus subtilis, Micrococcus luteus, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa), filamentous fungus (Aspergillus niger) and yeasts (Saccharomyces cerevisae, Candida albicans and Candida tropicallis), at the concentration of 1 mg/mL in agar diffusion assay.

【 授权许可】

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