Design, Synthesis and Antiviral Potential of 14-Aryl/Heteroaryl-14H-dibenzo[a,j]xanthenes Using an Efficient Polymer-Supported Catalyst

Molecules

Kalla Reddi Mohan Naidu¹  Balam Satheesh Krishna¹  Mungara Anil Kumar¹  Palanisamy Arulselvan¹  Shaik Ibrahim Khalivulla¹ 

[1] ¹Department of Food Technology, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia

关键词: aryl aldehydes;    2-naphthol;    PEG-OSO₃H;    neat reaction;    xanthenes;    tobacco mosaic virus;   

DOI  :  10.3390/molecules17067543

来源: mdpi

【 摘 要 】

Polyethyleneglycol bound sulfonic acid (PEG-OSO₃H), a chlorosulphonic acid-modified polyethylene glycol was successfully used as an efficient and eco-friendly polymeric catalyst in the synthesis of 14-aryl/heteroaryl-14H-dibenzo[a,j]xanthenes obtained from the reaction of 2-naphthol and carbonyl compounds under solvent-free conditions with short reaction times and excellent yields. The biological properties of these synthesized title compounds revealed that compounds 3b, 3c, 3f and 3i showed highly significant anti-viral activity against tobacco mosaic virus.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.