Reusable Nano-Zirconia-Catalyzed Synthesis of Benzimidazoles and Their Antibacterial and Antifungal Activities

Molecules

Naushad Ahmad¹  G. Rajasekhar Reddy²  Tentu Nageswara Rao³  Ravi Kumar Cheedarala⁴  Tentu Manohra Naidu⁵  Nalla Krishna Rao⁶  M. V. Basaveswara Rao⁶  Faheem Ahmed⁷  Suliman Yousef AlOmar⁸  Fadwa Albalawi⁸ 

[1] Chemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia;Department of Chemical Engineering, A.C Tech Campus, Anna University, Chennai 600025, India;Department of Chemistry, Krishna University, Machilipatnam 521001, Andhra Pradesh, India;Department of Materials Science and Engineering, Ulsan National Institute of Science and Technology, UNIST-Gil, Ulsan 44919, Korea;Department of Nuclear Physics, Andhra University, Visakhapatnam 530003, Andhra Pradesh, India;Department of Organic Chemistry, Krishna University, Machilipatnam 521001, Andhra Pradesh, India;Department of Physics, College of Science, King Faisal University, Hofuf 31982, Al-Ahsa, Saudi Arabia;Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia;

关键词: o-phenylenediamine;    nano-ZrO₂;    aryl aldehydes;    benzimidazole;    XRD;   

DOI  :  10.3390/molecules26144219

来源: DOAJ

【 摘 要 】

In this article, a zirconia-based nano-catalyst (Nano-ZrO₂), with intermolecular C-N bond formation for the synthesis of various benzimidazole-fused heterocycles in a concise method is reported. The robustness of this reaction is demonstrated by the synthesis of a series of benzimidazole drugs in a one-pot method. All synthesized materials were characterized using ¹HNMR, ¹³CNMR, and LC-MS spectroscopy as well as microanalysis data. Furthermore, the synthesis of nano-ZrO₂ was processed using a standard hydrothermal technique in pure form. The crystal structure of nano-ZrO₂ and phase purity were studied, and the crystallite size was calculated from XRD analysis using the Debye–Scherrer equation. Furthermore, the antimicrobial activity of the synthesized benzimidazole drugs was evaluated in terms of Gram-positive, Gram-negative, and antifungal activity, and the results were satisfactory.

【 授权许可】

Unknown