NDRG1 Controls Gastric Cancer Migration and Invasion through Regulating MMP-9

Pathology & Oncology Research

Dongqiu Dai²  Jing Chen³  Peng Deng³  Xiaojing Chang⁴  Jinguo Ma³  Shuanglong Zhang³  Yu Zhi³  Zhenhua Li³  Xiaoying Xue¹  Xiaoyang Xu³ 

[1] Hebei Medical University$$;China Medical University$$China Medical University$$China Medical University$$;China Medical University$$;China Medical University$$China Medical University$$Hebei Medical University$$

关键词: Metastasis;   

DOI  :  10.1007/s12253-016-0071-8

学科分类：生理学与病理学

来源: Springer

【 摘 要 】

The purpose of this study is to detect the clinical significance of NDRG1 and its relationship with MMP-9 in gastric cancer metastatic progression. 101 cases of gastric cancer specimens were utilized to identify the protein expression of NDRG1 and MMP-9 by immunohistochemistry, their clinical significance was also analyzed. The suppression by siRNA-NDRG1 was employed to detect the role of NDRG1 in gastric cancer progression and its relationship with MMP-9. NDRG1 expression was correlated inversely with the degree of tumor cell differentiation (p < 0.01), invasion depth (p < 0.05), lymph node metastasis (p < 0.05) and TNM stage (p < 0.05), whereas MMP-9 was positive correlated with the degree of tumor cell differentiation (p < 0.01), lymph node metastasis (p < 0.05) and TNM stage (p < 0.05), but not correlated with invasion depth (p>0.05). Furthermore, cell proliferation and invasion effect were remarkably enhanced when NDRG1 was silencing, but MMP-9 expression was increased. NDRG1 silencing enhances gastric cancer cells progression through upregulating MMP-9. It suggests that NDRG1 may inhibit the metastasis of gastric cancer via regulating MMP-9.

【 授权许可】

Unknown