Regulation of angiogenesis by hypoxia: the role of microRNA

Cellular & Molecular Biology Letters

Rafal Bartoszewski⁴  James F. Collawn¹  Niren Kapoor²  Zsuzsa Bebok¹  Piotr Madanecki³  Renata Ochocka³ 

[1] Department of Cell Biology, Developmental, and Integrative, University of Alabama at Birmingham, Birmingham, USA$$;Department of Neurology, University of Alabama at Birmingham, Birmingham, USA$$;Department of Biology and Pharmaceutical Botany, Medical University of Gdansk, Gdansk, Poland$$;Department of Biology and Pharmaceutical Botany, Medical University of Gdansk, Gdansk, Poland$$Department of Biology and Pharmaceutical Botany, Medical University of Gdansk, Gdansk, Poland$$

关键词: Angiogenesis;    Hypoxia;    microRNA;    miRNA;    HypoxamiR;    HIF;    VEGF;   

DOI  :  10.2478/s11658-012-0037-0

学科分类：分子生物学，细胞生物学和基因

来源: Uniwersytet Wroclawski * Wydzial Biotechnologii / University of Wroclaw, Faculty of Biotechnology

【 摘 要 】

Understanding the cellular pathways that regulate angiogenesis during hypoxia is a necessary aspect in the development of novel treatments for cardiovascular disorders. Although the pathways of angiogenesis have been extensively studied, there is limited information on the role of miRNAs in this process. miRNAs or their antagomirs could be used in future therapeutic approaches to regulate hypoxia-induced angiogenesis, so it is critical to understand their role in governing angiogenesis during hypoxic conditions. Although hypoxia and ischemia change the expression profile of many miRNAs, a functional role for a limited number of so-called hypoxamiRs has been demonstrated in angiogenesis. Here, we discuss the best examples that illustrate the role of hypoxamiRs in angiogenesis.

【 授权许可】

Unknown