L‐type voltage‐gated calcium channels: understanding function through structure

FEBS Letters

Dolphin, Annette²  Kitmitto, Ashraf¹  Wang, Ming-Chuan¹ 

[1] Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology (UMIST), Manchester M60 1QD, UK;Department of Pharmacology, University College London, Gower St. London WC1E 6BT, UK

关键词: L-type voltage-gated calcium channel;    Single particle analysis;    Electron microscopy;    Angular reconstitution;    Muscle excitation–contraction coupling;   

DOI  :  10.1016/S0014-5793(04)00253-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

L-type voltage-gated calcium channels (VGCCs) are multisubunit membrane proteins that regulate calcium influx into excitable cells. Within the last two years there have been four separate reports describing the structure of the skeletal muscle VGCC determined by electron microscopy and single particle analysis methods. There are some discrepancies between the structures, as well as reports for both monomeric and dimeric forms of the channel. This article considers each of the VGCC structures in terms of similarities and differences with an emphasis upon translation of data into a biological context.

【 授权许可】

Unknown