FEBS Letters | |
Gene expression profile linked to p53 status in hepatitis C virus‐related hepatocellular carcinoma | |
Yamada-Okabe, Hisafumi3  Takemoto, Norikazu2  Oka, Masaaki2  Hamamoto, Yoshihiko1  Iizuka, Norio2  Nakayama, Hironobu3  Tangoku, Akira2  Okada, Toshimasa2  Tamesa, Takao2  Mori, Naohide2  Miyamoto, Takanobu1  Hamada, Kenji3  Uchimura, Shunji1  | |
[1] Department of Computer Science and Systems Engineering, Faculty of Engineering, Yamaguchi University, 2-16-1 Tokiwadai, Ube, Yamaguchi 755-8611, Japan;Department of Surgery II, Yamaguchi University School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan;Pharmaceutical Research Department 4, Kamakaura Research Laboratories, Chugai Pharmaceutical Co. Ltd., 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan | |
关键词: p53; DNA chip; Gene expression; Hepatocellular carcinoma; Cancer; HCC; hepatocellular carcinoma; HCV; hepatitis C virus; wt-p53; wild-type p53; mt-p53; mutant-type p53; Gene abbreviations used are from LocusLink; | |
DOI : 10.1016/S0014-5793(03)01345-0 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
To clarify the role of p53 in 22 hepatitis C virus (HCV)-infected hepatocellular carcinomas (HCCs), we compared the gene expression profiles of HCCs with wild-type p53 (wt-p53) (n=17) and those with mutant-type p53 (mt-p53) (n=5) by oligonucleotide microarray analysis. Among 83 p53-related genes identified by a supervised learning method, 25 were underexpressed, and 58 were overexpressed in mt-p53 HCCs compared with wt-p53 HCCs. With a computer search, we identified consensus p53-binding sequences in the 3-kb region upstream of the translation initiation site in 59 of the 83 genes, suggesting that the in vivo p53-associated transcription system is very complicated. These data will provide additional insights into p53-related pathogenesis in HCV-infected HCC.
【 授权许可】
Unknown
【 预 览 】
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