Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development

Molecular Autism

Romy Evans¹  Fabrizio Rudari¹  Conor Mohan¹  Philipp Suetterlin¹  Shaun Hurley¹  Kimberley L. H. Riegman¹  Robert Ellingford¹  M. Albert Basson²  Olivier Brock³  Alessio Delogu³  Maria Luisa Scattoni⁴  Caterina Michetti⁵  Angela Caruso⁶  Jacob Ellegood⁷  Jason P. Lerch⁸  Cathy Fernandes⁹ 

[1] Centre for Craniofacial and Regenerative Biology, King’s College London, London, UK;Centre for Craniofacial and Regenerative Biology, King’s College London, London, UK;MRC Centre for Neurodevelopmental Disorders, King’s College London, London, UK;Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK;Department of Cell Biology and Neuroscience, Neurotoxicology and Neuroendocrinology Section, Istituto Superiore Di Sanità, Rome, Italy;Department of Cell Biology and Neuroscience, Neurotoxicology and Neuroendocrinology Section, Istituto Superiore Di Sanità, Rome, Italy;Centre for Synaptic Neuroscience and Technology, Istituto Italiano Di Tecnologia, Genova, Italy;Department of Cell Biology and Neuroscience, Neurotoxicology and Neuroendocrinology Section, Istituto Superiore Di Sanità, Rome, Italy;Department of Psychology, School of Behavioural Neuroscience, Sapienza University of Rome, Rome, Italy;Department of Medical Biophysics, Mouse Imaging Centre, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada;Department of Medical Biophysics, Mouse Imaging Centre, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada;Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK;MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK;MRC Centre for Neurodevelopmental Disorders, King’s College London, London, UK;

关键词: CHD8;    Chromatin;    TBR2;    Autism;    Cortex;    Hypomorph;    Conditional knockout;    Mouse;    Neural progenitor;    Intermediate progenitor;    p53;    Gene expression;    Proliferation;    Apoptosis;   

DOI  :  10.1186/s13229-020-00409-3

来源: Springer

【 授权许可】

CC BY