Multidrug resistance ABC transporters

FEBS Letters

Chang, Geoffrey¹ 

[1]Department of Molecular Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd. CB-105, La Jolla, CA 92037, USA

关键词: Multidrug resistance;    ATP binding cassette transporter;    Membrane protein;    X-ray crystallography;   

DOI  :  10.1016/S0014-5793(03)01085-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Clinical multidrug resistance is caused by a group of integral membrane proteins that transport hydrophobic drugs and lipids across the cell membrane. One class of these permeases, known as multidrug resistance ATP binding cassette (ABC) transporters, translocate these molecules by coupling drug/lipid efflux with energy derived from the hydrolysis of ATP. In this review, we examine both the structures and conformational changes of multidrug resistance ABC transporters. Together with the available biochemical and structural evidence, we propose a general mechanism for hydrophobic substrate transport coupled to ATP hydrolysis.

【 授权许可】

Unknown