Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF‐kB activation

FEBS Letters

Bergandi, Loredana¹  Aldieri, Elisabetta¹  Ghigo, Dario¹  Bosia, Amalia¹  Costamagna, Costanzo¹  Atragene, Daniela¹  Riganti, Chiara¹ 

[1] Department of Genetics, Biology and Biochemistry, Sezione di Biochimica, University of Torino, Via Santena 5/bis, 10126 Torino, Italy

关键词: Nitric oxide;    Nitric oxide synthase;    Artemisinin;    Parthenolide;    Malaria;    NF-kB;    IkB-α;    iNOS;    inducible nitric oxide synthase;    IL-1β;    interleukin-1 beta;    IFN-γ;    interferon-gamma;    TNF-α;    tumor necrosis factor-alpha;    LPS;    lipopolysaccharide;    FBS;    fetal bovine serum;    DMEM;    Dulbecco's minimum essential medium;    RT-PCR;    reverse transcriptase-polymerase chain reaction;    EMSA;    electrophoretic mobility shift assay;    IkB;    NF-kB inhibitor;   

DOI  :  10.1016/S0014-5793(03)00905-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Artemisinin is a natural product used as an alternative drug in the treatment of severe and multidrug-resistant malaria. In the present work we show that artemisinin shares with other sesquiterpene lactones the ability to inhibit the activation of the nuclear factor NF-kB: by this mechanism, artemisinin, as well as parthenolide, inhibits nitric oxide synthesis in cytokine-stimulated human astrocytoma T67 cells. These results suggest that artemisinin, in addition to its antiparasitic properties, could also exert a therapeutic effect on neurological complications of malaria.

【 授权许可】

Unknown