Interaction of alphamangostin and curcumin with dihydroartemisinin as antimalaria in vitro

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Tjahjani, S.^1 ; Syafruddin^2 ; Tjokropranoto, R.^1

Maranatha Christian University, Bandung, Indonesia^1

Hasanuddin University, Makassar, Indonesia^2

关键词: Active metabolites;    Antimalarial activity;    Artemisinin;    Combination therapy;    Dihydroartemisinin;    Mechanism of action;    Plasmodium falciparum;    Synergistic effect;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012017/pdf
DOI  :  10.1088/1755-1315/125/1/012017

来源: IOP

【 摘 要 】

To overcome malarial resistance tendency against the ACT (artemisinin-based combination therapy), several galenic preparations of Garciniamangostana L-rind and alphamangostin as the major xanthone in this rind have been studied, and they had antimalarial activity and showed its synergistic effect with artemisinin in vitro. Curcumin as anactive component of turmeric is also potentially to have antimalarial activity. This study aimed to evaluate the activity as antimalarial of curcumin and dihydroartemisinin, an active metabolite of all artemisinin derivates, and also to study the mechanism of action of aphamangostin, curcumin, and dihydroartemisinin as antimalaria.The interaction between them each other as the antimalarial in vitro was also investigated. The antimalarial activity was studied in in vitro 3D7 Plasmodium falciparum cultivation incubated with these compounds to look for the IC50and ΣFIC50of them. The mechanism of action of these compounds was observed electron microscopically. The result of this promising study showed that these compounds were active antimalaria agents which inhibited hemozoin formation and there is synergistic antimalarial activity interaction between alphamangostin and dihydroartemisinin.