Artesunate-amodiaquine efficacy in Congolese children with acute uncomplicated falciparum malaria in Brazzaville

Malaria Journal

Research

Dieudonné Loumouamou¹  Pembe Issamou Mayengue²  Francine Ntoumi²  Leonardo K Basco³  Philippe Brasseur⁴  Mathieu Ndounga⁵  Prisca Nadine Casimiro⁵ 

[1] Circonscription Socio-Sanitaire de Makélékélé, Ministère de la Santé, Brazzaville, République du Congo;Fondation Congolaise pour la Recherche Médicale (FCRM), BP 2672, Brazzaville, République du Congo;Faculté des Sciences de la Santé, Université Marien Ngouabi, BP 2672, Brazzaville, République du Congo;Institut de Recherche pour le Développement (IRD), Unité Mixte de Recherche 198, Unité de Recherche des Maladies Infectieuses et Tropicales Emergentes (URMITE), Faculté de Médecine La Timone, Université Aix-Marseille, Marseille, France;Laboratoire de Recherches sur le Paludisme, Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), Yaoundé, Cameroon;Institut de Recherche pour le Développement (IRD), Unité mixte de Recherche 198, BP 1386, Dakar, Sénégal;Unité de Recherche sur le Paludisme, Centre d’Etudes sur les Ressources Végétales (CERVE), BP 1249, Brazzaville, République du Congo;

关键词: Drug resistance;    Artemisinin;    Combination therapy;    Chloroquine;    Drug efficacy;    Congo-Brazzaville;   

DOI  :  10.1186/1475-2875-12-53

 received in 2012-11-23, accepted in 2013-01-29,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundCongo-Brazzaville adopted artemisinin-based combination therapy (ACT) in 2006. Artesunate-amodiaquine (AS + AQ) and artemether-lumefantrine are the first-line and second-line anti-malarial drugs to treat uncomplicated Plasmodium falciparum malaria, respectively. The baseline efficacy of AS + AQ was evaluated from February to August 2005 in patients living in Brazzaville, the capital city of the Republic of Congo.MethodsOne hundred and ninety-seven patients (96 ≤5 years old and 101 >5 years old, including adults) were recruited in a non-randomized study, treated under supervision with AS + AQ, and were followed up for 28 days in accordance with the 2003 World Health Organization protocol. Plasmodium falciparum recrudescent isolates from day 7 to day 28 were compared to pretreatment isolates by polymerase chain reaction (PCR) to distinguish between re-infection and recrudescence.ResultsThe overall efficacy of AS + AQ after PCR correction on day 28 was 94.4%. An adequate clinical and parasitological response was observed in 94.3% and 94.4% of children aged ≤5 years old and those aged >5 years old (including adults), respectively. The main reported adverse events were dizziness, vomiting, diarrhoea, pruritus, headache, anorexia, and abdominal pain.ConclusionThis study has shown the high efficacy of AS + AQ in Congolese patients of all ages with acute uncomplicated falciparum malaria and serves as the baseline efficacy and tolerance of this ACT in Brazzaville.

【 授权许可】

CC BY   
© Ndounga et al.; licensee BioMed Central Ltd. 2013