The dual role of protein kinase C in the regulation of telomerase activity in human lymphocytes

FEBS Letters

Chien, Ya-Li¹  Sheng, Wei-Yun¹  Wang, Tzu-Chien V¹ 

[1] Department of Molecular and Cellular Biology, Chang Gung University, Kwei-San, Tao-Yuan 333, Taiwan

关键词: Protein kinase C;    hTERT;    Telomerase;    T cell activation;   

DOI  :  10.1016/S0014-5793(03)00230-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Protein kinase C (PKC) has been implicated to play an essential function in the upregulation of telomerase activity in activated T cells, yet its role in the regulation of telomerase activity remains largely unknown. In this work, we present evidence that PKC activity is required both for the induction of hTERT expression and for the post-transcriptional control of telomerase enzyme activity in T lymphocytes. Of the several PKC isoforms present in lymphocytes, only the level of PKC-ζ was greatly increased during T cell activation, implicating that PKC-ζ may be required for the post-transcriptional control of telomerase enzyme activity in T lymphocytes.

【 授权许可】

Unknown