β1/β2/β3‐adrenoceptor knockout mice are obese and cold‐sensitive but have normal lipolytic responses to fasting

FEBS Letters

Arboit, Patrizia²  Canola, Kriss²  Russell, Aaron P²  Giacobino, Jean-Paul²  Preitner, Frédéric²  Seydoux, Josiane¹  Léger, Bertrand²  Lehr, Lorenz²  Muzzin, Patrick²  Jimenez, Maria² 

[1] Département de Physiologie, Centre Médical Universitaire, 1211 1, rue Michel-Servet, Genève 4, Switzerland;Département de Biochimie Médicale, Centre Médical Universitaire, 1, rue Michel-Servet, 1211 Genève 4, Switzerland

关键词: β-Adrenergic;    Obesity;    Uncoupling protein;    Fasting;    Thermogenesis;   

DOI  :  10.1016/S0014-5793(02)03387-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Catecholamines are viewed as major stimulants of diet- and cold-induced thermogenesis and of fasting-induced lipolysis, through the β-adrenoceptors (β₁/β₂/β₃). To test this hypothesis, we generated β₁/β₂/β₃-adrenoceptor triple knockout (TKO) mice and compared them to wild type animals. TKO mice exhibited normophagic obesity and cold-intolerance. Their brown fat had impaired morphology and lacked responses to cold of uncoupling protein-1 expression. In contrast, TKO mice had higher circulating levels of free fatty acids and glycerol at basal and fasted states, suggesting enhanced lipolysis. Hence, β-adrenergic signalling is essential for the resistance to obesity and cold, but not for the lipolytic response to fasting.

【 授权许可】

Unknown