Tissue‐dependent upregulation of rat uncoupling protein‐2 expression in response to fasting or cold

FEBS Letters

Giacobino, Jean-Paul¹  Samec, Sonia²  Dulloo, Abdul²  Seydoux, Josiane²  Boss, Olivier¹ 

[1] Department of Medical Biochemistry, Faculty of Medicine, University of Geneva, 1 Michel Servet, 1211 Geneva 4, Switzerland;Department of Physiology, Faculty of Medicine, University of Geneva, 1 Michel Servet, 1211 Geneva 4, Switzerland

关键词: Uncoupling protein;    Skeletal muscle;    Heart;    Brown adipose tissue;    Fasting;    Cold;    UCP;    uncoupling protein;    BAT;    brown adipose tissue;   

DOI  :  10.1016/S0014-5793(97)00755-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The control of uncoupling protein-2 (UCP2) mRNA expression in rat brown adipose tissue (BAT), heart and skeletal muscles was examined. Cold exposure (48 h) increased UCP2 mRNA in BAT, heart and soleus muscle by 2.4-, 4.3- and 2.6-fold, respectively. Fasting (48 h) had no effect on UCP2 mRNA expression neither in BAT nor in heart, but markedly increased it in skeletal muscles. While the upregulation of UCP2 mRNA in response to cold exposure is in line with a putative uncoupling role for this protein in thermoregulatory thermogenesis, the unexpected upregulation of UCP2 in skeletal muscles in response to fasting seems inconsistent with its role as an uncoupling protein involved in dietary regulation of thermogenesis.

【 授权许可】

Unknown