Latent TGF‐β binding protein‐3 (LTBP‐3) requires binding to TGF‐β for secretion

FEBS Letters

Annes, Justin P¹  Rifkin, Daniel B¹  Chen, Yan¹  Dabovic, Branka¹ 

[1] Departments of Cell Biology and Medicine, New York University School of Medicine, New York, NY 10016, USA

关键词: Latent transforming growth factor-β binding protein;    Transforming growth factor-β;    TGF-β;    transforming growth factor-β;    LTBP;    latent TGF-β binding protein;    LAP;    latency-associated peptide;    EGF;    epidermal growth factor;   

DOI  :  10.1016/S0014-5793(02)02648-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Latent transforming growth factor-β (TGF-β) binding protein (LTBP)-1, which is easily secreted, has been shown to enhance the secretion of TGF-β. Here we show that another member of the LTBP family, LTBP-3, is not secreted by several cell types, but secretion occurs after coexpression with TGF-β. The secretion of LTBP-3 requires complexing of LTBP-3 with Cys33 of the TGF-β propeptide.

【 授权许可】

Unknown