Activation of Epstein‐Barr virus promoters by a growth‐factor and a glucocorticoid

FEBS Letters

Chasserot-Golaz, S.¹  Beck, G.¹  Schuster, C.¹ 

[1] Institut de Biologie Moléculaire et Cellulaire du CNRS, 15 rue René Descartes, 67000 Strasbourg, France

关键词: Transforming growth factor-β;    Dexamethasone;    Transcription;    Early antigen;    Epstein-Barr virus;    Lymphoma cell;    CAT;    chloramphenicol acetyl transferase;    DR;    duplicate right;    DXM;    dexamethasone (9α-fluoro-16α-methyl-11β;    17α;    21-trihydroxy-1;    4-pregna-diene-3;    20-dione);    EA;    early antigens;    EBV;    Epstein-Barr virus;    NFI;    nuclear factor 1;    TGF-β;    transforming growth factor-β;    TPA;    12-O-tetradecanoyl-phorbol 13-acetate;    RU486;    17β-hydroxy-11β-(4-dimethylaminophenyl)-17α-(1-propynyl)-estra-4;    9-diene-3-one;   

DOI  :  10.1016/0014-5793(91)80767-W

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Transforming growth factor-β (TGF-β) and a glucocorticosteroid, Dexamethasone (DXM), both cause transcriptional induction of Epstein-Barr virus (EBV) early antigens (EA) in Daudi lymphoma cells. The viral induction occurs through the viral promoter DR overlapping an origin of replication which is active during the lytic cycle. Each hormone requires specific regions on the DR promoter. Since these regions also mediate the action of two viral transcription factors, EBI and R, it may be emphasized that EBI and/or R are involved in the EA induction process by TGF-β and by DXM.

【 授权许可】

Unknown