CLK‐1 protein has DNA binding activity specific to OL region of mitochondrial DNA

FEBS Letters

Seluanov, Andrei¹  Gorbunova, Vera¹ 

[1] Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA

关键词: Aging;    Mitochondrion;    OL-hairpin;    Caenorhabditis elegans;    clk-1;   

DOI  :  10.1016/S0014-5793(02)02568-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Mutations in the clk-1 gene of Caenorhabditis elegans extend worm life span and slow down a variety of physiological processes. Here we report that C. elegans CLK-1 as well as its mouse homologue have DNA binding activity that is specific to the O_L region of mitochondrial DNA. DNA binding activity of CLK-1 is inhibited by ADP, and is altered by mutations that extend nematode life span. Our results suggest that, in addition to its enzymatic function in ubiquinone biosynthesis, CLK-1 is involved in the regulation of mtDNA replication or transcription.

【 授权许可】

Unknown