Mitochondria, aging and longevity – a new perspective

FEBS Letters

Franceschi, Claudio²  Bonafè, Massimiliano²  Salvioli, Stefano²  Capri, Miriam²  Monti, Daniela¹ 

[1] Department of Experimental Pathology and Oncology, University of Florence, Florence, Italy;Department of Experimental Pathology, University of Bologna, Section of Immunology and Microbiology, Via S. Giacomo, 12, 40126 Bologna, Italy

关键词: Mitochondrion;    Aging;    Longevity;    Apoptosis;    ROS;    reactive oxygen species;    mtDNA;    mitochondrial DNA;    MMP;    mitochondrial membrane potential;    PT;    permeability transition;   

DOI  :  10.1016/S0014-5793(01)02199-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A new perspective is emerging indicating that mitochondria play a critical role in aging not only because they are the major source and the most proximal target of reactive oxygen species, but also because they regulate stress response and apoptosis. Recent literature indicates that, in response to stress, a variety of molecules translocate to and localise in mitochondria. These molecules are likely to interact with each other, in order to mediate mitochondria/nucleus cross-talk and to regulate apoptosis. We surmise that an integration of signals in multimolecular complexes occurs at mitochondrial level. These phenomena can be of critical importance for human aging and longevity.

【 授权许可】

Unknown