Neuronal Inputs and Outputs of Aging and Longevity

Frontiers in Genetics

Joy eAlcedo¹  Elena G. Pasyukova³  Thomas eFlatt⁴ 

[1] Friedrich Miescher Institute for Biomedical Research;Institute for Advanced Study;Russian Academy of Sciences;University of Lausanne;Vetmeduni Vienna;Wayne State University;

关键词: Aging;    Brain;    Homeostasis;    Longevity;    Nervous System;    Neuroendocrine System;   

DOI  :  10.3389/fgene.2013.00071

来源: DOAJ

【 摘 要 】

An animal’s survival strongly depends on its ability to maintain homeostasis in response to the changing quality of its external and internal environment. This is achieved through intracellular and intercellular communication within and among different tissues. One of the organ systems that plays a major role in this communication and the maintenance of homeostasis is the nervous system. Here we highlight different aspects of the neuronal inputs and outputs of pathways that affect aging and longevity. Accordingly, we discuss how sensory inputs influence homeostasis and lifespan through the modulation of different types of neuronal signals, which reflects the complexity of the environmental cues that affect physiology. We also describe feedback, compensatory and feed-forward mechanisms in these longevity-modulating pathways that are necessary for homeostasis. Finally, we consider the temporal requirements for these neuronal processes and the potential role of natural genetic variation in shaping the neurobiology of aging.

【 授权许可】

Unknown