Novel anti-aging herbal formulation Jing Si displays pleiotropic effects against aging associated disorders

Biomedicine & Pharmacotherapy

Tsung-Jung Ho¹  Wei-Wen Kuo²  Chih-Yang Huang³  Shinn-Zong Lin⁴  Pi-Yu Lin⁵  Md. Nazmul Islam⁶  Marthandam Asokan Shibu⁶  Debakshee Goswami⁶  Chien-Yi Chiang⁶  Cheng-You Lu⁶  Surbhi Agarwal⁶  Navaneethan Sundhar⁶  Yu-Jung Lin⁶  Wan-Ting Tsai⁷ 

[1] Department of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan;Integration Center of Traditional Chinese and Modern Medicine, Hualien Tzu Chi Hospital, Hualien 97002, Taiwan;School of Post‑Baccalaure‑ate Chinese Medicine, College of Medicine, Tzu Chi University, Hualien 97004, Taiwan;Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan;Buddhist Tzu Chi Charity Foundation, Hualien 970, Taiwan;Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan;Department of Chinese Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien, Taiwan;

关键词: Multitarget drugs;    Aging;    Diabetes;    Cardiac diseases;    Oncogenesis;    Homeostasis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Common characteristics of aging include reduced somatic stem cell number, susceptibility to cardiac injuries, metabolic imbalances and increased risk for oncogenesis. In this study, Pleiotropic anti-aging effects of a decoction Jing Si herbal drink (JS) containing eight Traditional Chinese Medicine based herbs, with known effects against aging related disorders was evaluated. Adipose derived mesenchymal stem cells (ADMSCs) from 16 week old adult and 24 month old aging WKY rats were evaluated for the age-related changes in stem cell homeostasis. Effects of JS on self-renewal, klotho and Telomerase Reverse Transcriptase expression DNA damage response were determined by immunofluorescence staining. The effects were confirmed in senescence induced human ADMSCs and in addition, the potential of JS to maintain telomere length was evaluated by qPCR analysis in ADMSCs challenged for long term with doxorubicin. Further, the effects of JS on doxorubicin-induced hypertrophic effect and DNA damage in H9c2 cardiac cells; MPP+-induced damages in SH-SY5Y neuron cells were investigated. In addition, effects of JS in maintaining metabolic regulation, in terms of blood glucose regulation in type-II diabetes mice model, and their potential to suppress malignancy in different cancer cells were ascertained. The results show that JS maintains stem cell homeostasis and provides cytoprotection. In addition JS regulates blood glucose metabolism, enhances autophagic clearances in neurons and suppresses cancer growth and migration. The results show that JS acts on multiple targets and provides a cumulative protective effect against various age-associated disorders and therefore it is a candidate pleiotropic agent for healthy aging.

【 授权许可】

Unknown