Uncoupling proteins outside the animal and plant kingdoms: functional and evolutionary aspects

FEBS Letters

Sluse, Francis E.¹  Jarmuszkiewicz, Wieslawa² 

[1] Laboratory of Bioenergetics, Institute of Chemistry B6, University of Liège, Sart Tilman, B-4000 Liège, Belgium;Department of Bioenergetics, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Fredry, 10, 61-701 Poznan, Poland

关键词: Mitochondrion;    Uncoupling protein;    Alternative oxidase;    Acanthamoeba castellanii;    Candida parapsilosis;    Dictyostelium discoideum;    AOX;    alternative oxidase;    EF-1α;    protein synthesis elongation factor;    FCCP;    carbonyl cyanide p-trifluoromethoxyphenylhydrazone;    FFA;    free fatty acids;    LA;    linoleic acid;    MACP;    mitochondrial anion carrier protein;    PUMP;    plant uncoupling mitochondrial protein;    ROS;    reactive oxygen species;    state 3;    phosphorylating respiration in the presence of ADP;    state 4;    resting respiration in the absence of added ADP;    UCP;    uncoupling protein;    UCP1;    uncoupling protein of brown adipose tissue;    Δμ̃H+;    proton electrochemical gradient;   

DOI  :  10.1016/S0014-5793(01)03229-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The appearance of intracellular oxidative phosphorylation at the time of acquisition of mitochondria in Eukarya was very soon accompanied by the emergence of uncoupling protein, a carrier specialized in free fatty acid-mediated H⁺ recycling that can modulate the tightness of coupling between mitochondrial respiration and ATP synthesis, thereby maintaining a balance between energy supply and demand in the cell and defending cells against damaging reactive oxygen species production when electron carriers of the respiratory chain become overreduced. The simultaneous occurrence of redox free energy-dissipating oxidase, which has the same final effect, could be related to the functional interactions between both dissipative systems.

【 授权许可】

Unknown