The effect of β‐carotene on the expression of interleukin‐6 and heme oxygenase‐1 in UV‐irradiated human skin fibroblasts in vitro

FEBS Letters

Obermüller-Jevic, Ute C.¹  Biesalski, Hans Konrad¹  Schlegel, Beate¹  Flaccus, Andrea¹ 

[1] Department of Biological Chemistry and Nutrition, University of Hohenheim, Fruwirthstrasse 12, 70593 Stuttgart, Germany

关键词: β-Carotene;    Interleukin-6;    Heme oxygenase-1;    UVA;    UVB;    Singlet oxygen;    IL-6;    interleukin-6;    HO-1;    heme oxygenase-1;    1O2;    singlet molecular oxygen;    p.i.;    post irradiation;    BC;    β-carotene;    NaN3;    sodium azide;    DIG;    digoxigenin;   

DOI  :  10.1016/S0014-5793(01)03169-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

β-Carotene is discussed as an anti-oxidant micronutrient and singlet oxygen quencher in human skin, protecting against UV light-induced damage. However, we recently demonstrated that β-carotene has a pro-oxidant potential in cultured human skin fibroblasts because it enhances the UVA induction of heme oxygenase-1 (HO-1). Herein, we further show that β-carotene also strongly promotes the UVA induction of pro-inflammatory interleukin-6 (IL-6) in skin fibroblasts in vitro. Singlet oxygen quencher sodium azide abrogated up-regulation of IL-6, and likewise also of HO-1. In UVB-irradiated cells, β-carotene did not modulate levels of IL-6 and HO-1. The observed effects might be relevant for UV-induced inflammatory processes.

【 授权许可】

Unknown