β‐Carotene with vitamins E and C offers synergistic cell protection against NOx

FEBS Letters

Truscott, T.G.¹  McGarvey, D.J.¹  Edge, R.¹  Böhm, F.² 

[1] Department of Chemistry, Keele University, Keele, Staffs. ST5 5BG, UK;Department of Dermatology (Charité), Humboldt University, 10117 Berlin, Germany

关键词: β-Carotene;    Lymphocyte;    Peroxynitrite;    Nitrogen dioxide;    Vitamin E;    Vitamin C;   

DOI  :  10.1016/S0014-5793(98)01173-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The peroxynitrite anion and the nitrogen dioxide (radical) are important toxic species which can arise in vivo from nitric oxide. Both in vivo and in vitro cell protection is demonstrated for β-carotene in the presence of vitamin E and vitamin C. A synergistic protection is observed compared to the individual anti-oxidants and this is explained in terms of an electron transfer reaction in which the β-carotene radical is repaired by vitamin C.

【 授权许可】

Unknown