Enhancement of the UVA induction of haem oxygenase‐1 expression by β‐carotene in human skin fibroblasts

FEBS Letters

Frank, Jürgen¹  Biesalski, Hans K¹  Obermüller-Jevic, Ute C¹  Francz, Pal I¹  Flaccus, Andrea¹ 

[1] Department of Biological Chemistry and Nutrition, University of Hohenheim, Fruwirthstraße 12, D-70593 Stuttgart, Germany

关键词: β-Carotene;    Vitamin E;    Vitamin C;    Hemoxygenase;    Ultraviolet A;    Oxidative stress;    HO-1;    haem oxygenase-1;    UVA;    ultraviolet A;    UVB;    ultraviolet B;    MβCD;    methyl-β-cyclodextrin;    p.i.;    post irradiation;   

DOI  :  10.1016/S0014-5793(99)01342-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

β-Carotene has often been discussed as a means to reduce the risk of skin photodamage. We studied the antioxidative potential of β-carotene in human skin fibroblasts exposed to ultraviolet A light. Surprisingly, we found a pro-oxidative effect of β-carotene. Using the induction of haem oxygenase-1 as a marker for oxidative stress, we found a strong enhancement of gene expression by β-carotene in ultraviolet A-irradiated cells. This effect was clearly suppressed by concomitant addition of vitamin E but only moderately by vitamin C. The results show that β-carotene has pro-oxidative properties in human skin fibroblasts exposed to ultraviolet-A light.

【 授权许可】

Unknown