The protein phosphatase 2A B′‐regulatory subunit par1p is implicated in regulation of the S. pombe septation initiation network

FEBS Letters

Le Goff, Xavier¹  Simanis, Viesturs¹  Schmidt, Susanne¹  Salimova, Ekaterina¹  Guerry, Frédéric¹  Cano, Elena¹  Cueille, Nathalie¹  Buvelot, Stéphanie¹ 

[1] Cell Cycle Control Laboratory, Swiss Institute for Experimental Cancer Research (ISREC), 1066 Epalinges, Switzerland

关键词: Cell cycle;    Septation;    Cytokinesis;    Phosphatase;    Kinase;   

DOI  :  10.1016/S0014-5793(01)03047-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In order to identify regulators of the Schizosaccharomyces pombe septation initiation network (SIN), which signals the onset of cell division, we have isolated extragenic suppressors of mutations in the GTPase spg1p, which is a central element in this pathway. One of these encodes the protein phosphatase 2A (PP2A) B′-regulatory subunit par1p. Loss of par1p function rescues mutants in cdc11, cdc7, and spg1, but no other SIN mutants. Our data suggest that PP2A-par1p acts as a negative regulator of SIN signalling.

【 授权许可】

Unknown