Protein translocation machineries of peroxisomes

FEBS Letters

Erdmann, Ralf¹  Holroyd, Claudia¹ 

[1] Freie Universität Berlin, Institut für Chemie/Biochemie, Thielallee 63, 14195 Berlin, Germany

关键词: Peroxisome biogenesis;    Protein targeting;    Peroxin;    PTS;    peroxisomal targeting signal;    PMP;    peroxisomal membrane protein;    TPR;    tetratricopeptide repeats;    SH3;    Src homology 3;    ER;    endoplasmic reticulum;   

DOI  :  10.1016/S0014-5793(01)02617-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Targeting of peroxisomal matrix and membrane proteins is performed by distinct transport machineries and requires the concerted action of at least 23 peroxins. Cargo recognition takes place in the cytosol and the multiple binding sites for peroxisomal signal sequence receptors at the peroxisomal membrane reflect the existence of an import cascade where the cargo-loaded receptors successively interact with different components of the import machinery. These interactions are likely to trigger conformational changes of the proteins within the import cascade which are required for the consecutive steps of peroxisomal protein import: docking, translocation, cargo release and receptor recycling.

【 授权许可】

Unknown