Fenofibrate prevents and reduces body weight gain and adiposity in diet‐induced obese rats

FEBS Letters

Lanni, A²  Goglia, F³  Colantuoni, V³  Mancini, F.P³  Contaldo, F¹  Giannino, A¹  Sabatino, L³  Moreno, M³ 

[1] Dipartimento di Medicina Clinica e Sperimentale, Universita’ di Napoli ‘Federico II’, Via S. Pansini 5, 80131 Naples, Italy;Dipartimento di Scienze della Vita, Seconda Universita’ di Napoli, Via Vivaldi 43, 81100 Caserta, Italy;Facolta’ di Scienze Matematiche, Fisiche e Naturali, Universita’ del Sannio, Via Port'Arsa 11, 82100 Benevento, Italy

关键词: Fibrate;    Obesity;    Fatty acid;    Peroxisome;    Mitochondrion;    Liver;    PPAR;    peroxisome proliferator-activated receptor;    FF;    fenofibrate;    UCP;    uncoupling protein;    WAT;    white adipose tissue;    GAPDH;    glyceraldehyde 3-phosphate dehydrogenase;    ACO;    acyl-CoA oxidase;    LPL;    lipoprotein lipase;    RT-PCR;    reverse transcriptase-polymerase chain reaction;   

DOI  :  10.1016/S0014-5793(01)02146-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Fibrates are hypolipidemic drugs that activate the peroxisome proliferator-activated receptors. Since fibrates may also increase energy expenditure, we investigated whether fenofibrate (FF) had this effect in diet-induced obese rats. A 2-month administration of a high-fat palatable diet to adult rats increased body weight by 25% and white adipose mass by 163% compared with a standard diet. These effects were prevented by FF, both when administered for the 2 months of high-fat feeding and when given for only the second month. Consequently, FF-treated rats had a final body weight and white adipose tissue mass similar to untreated animals on the standard diet. FF also increased resting metabolic rate, hepatic peroxisomal and mitochondrial palmitoyl-dependent oxygen uptake and mRNA levels of acyl-CoA oxidase and lipoprotein lipase. Finally, FF lowered mRNA levels of uncoupling protein-2 and did not affect mitochondrial respiration in skeletal muscle. Therefore, FF seems to act as a weight-stabilizer mainly through its effect on liver metabolism.

【 授权许可】

Unknown