Mitochondria: execution central

FEBS Letters

Gottlieb, Roberta A.¹ 

[1] Molecular and Experimental Medicine, MEM 220, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA

关键词: Mitochondrion;    Apoptosis;    Caspase;    Cytochrome c;    Bcl-2 homolog;    AIF;    apoptosis initiating factor;    ANT;    adenine nucleotide translocator;    CPT I;    carnitine palmitoyl transferase I;    IAP;    inhibitor of apoptosis protein;    PTP;    permeability transition pore;    VDAC;    voltage-dependent anion channel;   

DOI  :  10.1016/S0014-5793(00)02010-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Mitochondria play an essential function in eukaryotic life and death. They also play a central role in apoptosis regulation, reflected by the convergence of Bcl-2 family members on the mitochondrial outer membrane, and the presence of ‘death factors’ in the intermembrane space. Mitochondrial structure and function must be taken into consideration when evaluating mechanisms for cytochrome c release. The core machinery for caspase activation is conserved from Caenorhabditis elegans to man, and we consider parallels in the role of mitochondria in this process.

【 授权许可】

Unknown