FEBS Letters | |
Serum amyloid A‐derived peptides, present in human rheumatic synovial fluids, induce the secretion of interferon‐γ by human CD4 + T‐lymphocytes | |
Preciado-Patt, Liana2  Suessmuth, Roderich D.3  Yavin, Eran J.2  Levartowsky, David1  Lider, Ofer4  Rosen, Oren2  Yaron, Michael1  Jung, Gunther3  Fridkin, Mati2  | |
[1] Institute of Medical Research, Sourasky Medical Center, Tel-Aviv, Israel;Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, Israel;Institut für Organische Chemie, Universität Tübingen, Tübingen, Germany;Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel | |
关键词: Serum amyloid A; Inflammation; Interferon-γ; T-lymphocyte; APP; acute-phase protein; IFNγ; interferon-γ; PHA; phytohemoagglutinin; SAA; human serum amyloid A; | |
DOI : 10.1016/S0014-5793(00)01470-8 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Serum amyloid A (SAA) is a major acute-phase protein whose biochemical functions remain largely obscure. Human rheumatic synovial fluids were screened by high performance liquid chromatography mass spectrometry for SAA-derived peptides, specifically the sequence AGLPEKY (SAA98–104) which was previously shown to modulate various leukocyte functions. Two such fluids were found to contain a truncated version of SAA98–104. Synthetic SAA98–104 and several of its analogs were shown capable of binding isolated human CD4 + T-lymphocytes and stimulating them to produce interferon-γ. Given the high acute-phase serum level of SAA and its massive proteolysis by inflammatory related enzymes, SAA-derived peptides may be involved in host defense mechanisms.
【 授权许可】
Unknown
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