Serum amyloid A‐derived peptides, present in human rheumatic synovial fluids, induce the secretion of interferon‐γ by human CD4 + T‐lymphocytes

FEBS Letters

Preciado-Patt, Liana²  Suessmuth, Roderich D.³  Yavin, Eran J.²  Levartowsky, David¹  Lider, Ofer⁴  Rosen, Oren²  Yaron, Michael¹  Jung, Gunther³  Fridkin, Mati² 

[1] Institute of Medical Research, Sourasky Medical Center, Tel-Aviv, Israel;Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, Israel;Institut für Organische Chemie, Universität Tübingen, Tübingen, Germany;Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel

关键词: Serum amyloid A;    Inflammation;    Interferon-γ;    T-lymphocyte;    APP;    acute-phase protein;    IFNγ;    interferon-γ;    PHA;    phytohemoagglutinin;    SAA;    human serum amyloid A;   

DOI  :  10.1016/S0014-5793(00)01470-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Serum amyloid A (SAA) is a major acute-phase protein whose biochemical functions remain largely obscure. Human rheumatic synovial fluids were screened by high performance liquid chromatography mass spectrometry for SAA-derived peptides, specifically the sequence AGLPEKY (SAA_98–104) which was previously shown to modulate various leukocyte functions. Two such fluids were found to contain a truncated version of SAA_98–104. Synthetic SAA_98–104 and several of its analogs were shown capable of binding isolated human CD₄ ⁺ T-lymphocytes and stimulating them to produce interferon-γ. Given the high acute-phase serum level of SAA and its massive proteolysis by inflammatory related enzymes, SAA-derived peptides may be involved in host defense mechanisms.

【 授权许可】

Unknown