期刊论文详细信息
FEBS Letters | |
Ribozyme mediated cleavage of acute phase serum amyloid A (A‐SAA) mRNA in vitro | |
Gaughan, Derval J.1  Steel, Diana M.1  Whitehead, Alexander S.1  | |
[1] Department of Genetics and Biotechnology Institute, Trinity College, University of Dublin, Dublin, Ireland | |
关键词: Acute phase response; Hammerhead ribozyme; Inflammation; Serum amyloid A; A-SAA; acute-phase serum amyloid A; HDL; high density lipoprotein; SAA; serum amyloid A; | |
DOI : 10.1016/0014-5793(95)01118-X | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The 1000-fold induction of acute phase serum amyloid A (A-SAA) in the liver during inflammation indicates that this protein plays an important, though ill-defined, role in host defence. Paradoxically, prolonged overproduction of A-SAA is a causative factor in secondary amyloidosis and possibly other diseases such as atherosclerosis; the ability to down-regulate A-SAA synthesis is therefore of considerable clinical importance. We have successfully generated anti-SAA hammerhead ribozymes and we report that they are capable of cleaving A-SAA mRNA in vitro.
【 授权许可】
Unknown
【 预 览 】
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RO201912020301817ZK.pdf | 545KB | download |