Interplay between acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria

Allergy, Asthma & Clinical Immunology

A. Damasiewicz-Bodzek¹  R. Grzanka²  A. Kasperska-Zajac² 

[1] Department of Chemistry, SMDZ in Zabrze, Medical University of Silesia in Katowice;Department of Internal Diseases, Dermatology and Allergology, SMDZ in Zabrze, Medical University of Silesia in Katowice;

关键词: D-dimer;    CRP;    Inflammation;    Chronic spontaneous urticaria;    Coagulation/fibrinolysis;    Acute phase response;   

DOI  :  10.1186/s13223-018-0255-8

来源: DOAJ

【 摘 要 】

Abstract Background Chronic spontaneous urticaria (CSU) is associated with activation of systemic inflammatory response and coagulation/fibrinolysis. Aim To study whether there is a relationship between the acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria (CSU) patients. Methods Serum concentrations of C-reactive protein (CRP) and interleukin 6 (IL-6), key markers of acute phase response and of D-dimer, a marker of fibrin turnover were investigated in 58 CSU patients assessed with the urticaria activity score (UAS) and the controls. Results Serum concentrations of IL-6, CRP, and D-dimer were significantly higher in CSU patients as compared with the controls. We found statistically significant correlations between D-dimers concentrations and the inflammatory markers: CRP and IL-6 as well as UAS. Conclusions Markers of inflammation (IL-6 and CRP) and of fibrinolysis (D-dimer) are related to each other in CSU, suggesting a possible cross-talk between inflammation and coagulation/fibrinolysis. It might be implicated in pathogenesis of the disease and may be associated with higher risks of cardiovascular diseases in CSU patients.

【 授权许可】

Unknown