Termination of IL‐6‐induced STAT activation is independent of receptor internalization but requires de novo protein synthesis

FEBS Letters

Haan, Claude¹  Thiel, Stefan¹  Kortylewski, Marcin¹  Behrmann, Iris¹  Sommer, Ulrike¹  Heinrich, Peter C¹  Graeve, Lutz¹ 

[1] Institute of Biochemistry, Rheinisch-Westfälische Technische Hochschule Aachen, Pauwelsstr. 30, 52057 Aachen, Germany

关键词: Endocytosis;    gp130;    Interleukin-6;    Desensitization;    Jak/STAT signaling;    STAT;    signal transducer and activator of transcription;    IL;    interleukin;    Jak;    Janus kinase;    MAPK;    mitogen activated protein kinase;    SOCS;    suppressor of cytokine signaling;    PIAS;    protein inhibitors of activated STATs;    EPO;    erythropoietin;    EGF;    epidermal growth factor;    sIL-6R;    soluble IL-6 receptor;   

DOI  :  10.1016/S0014-5793(00)01276-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In this paper we have studied whether the down-modulation of the STAT signal requires the endocytosis of the receptor complex. Our results suggest that the desensitization of the IL-6 signal is not due to internalization of the receptor complex but requires de novo protein synthesis.

【 授权许可】

Unknown