Mechanical desensitization of explosives (e.g. by compaction) has important technological consequences for safety and performance. Many widely-used reactive flow models are not capable of reproducing the desensitisation observed in experiments such as measurements of double-shock particle velocity profiles. Improved models are under development, in which we intend to incorporate enough flexibility to reproduce experimentally observed shock desensitisation while retaining plausible and computationally practical physical models for the equations of state (unreacted, partially-reacted and products), equilibration processes and reaction rate. One application of experimental and reactive flow studies is to suggest ways of minimising the damage caused by explosives. Shock desensitisation on microsecond time scales may not be directly relevant to this application, but the reactive flow models deduced might indicate how and to what extent reaction can be influenced by manipulating the external environment.