Preferential induction of apoptosis of leukaemic cells by farnesol

FEBS Letters

Pizzey, Arnold R²  Thomas, N.Shaun B²  Marson, Charles M¹  Rioja, Alphonso¹ 

[1] Department of Chemistry, Queen Mary and Westfield College, Mile End Road, London E1 4NS, UK;Department of Haematology, Royal Free and University College Medical School, 98 Chenies Mews, London WC1E 6HX, UK

关键词: Farnesol;    Apoptosis;    Cell cycle;    Leukemia;   

DOI  :  10.1016/S0014-5793(00)01168-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Farnesol preferentially inhibits proliferation and induces apoptosis of tumour-derived but not non-transformed cell lines. We investigated whether farnesol induces apoptosis of blasts from patients with acute myeloid leukaemia (AML) and leukaemic cell lines, as compared with normal, human primary haemopoietic cells. We show that 30 μM farnesol causes apoptosis of leukaemic cell lines of T- and B-lymphocyte, myeloid or erythroid lineages and primary blasts obtained from patients with AML. However, the same concentration did not kill primary monocytes, or quiescent or proliferating T-lymphocytes. We conclude that farnesol selectively kills AML blasts and leukaemic cell lines in preference to primary haemopoietic cells.

【 授权许可】

Unknown