Stabilization of iron regulatory protein 2, IRP2, by aluminum

FEBS Letters

Minato, Nagahiro¹  Yamanaka, Koji¹  Iwai, Kazuhiro¹ 

[1] Department of Molecular and System Biology, Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan

关键词: Iron responsive element;    Iron regulatory protein;    Aluminum;    Iron metabolism;    Metal-catalyzed oxidation;    IRE;    iron responsive element;    IRP;    iron regulatory protein;    Df;    desferrioxamine;    FAC;    ferric ammonium citrate;    TfR;    transferrin receptor;    UTR;    untranslated region;   

DOI  :  10.1016/S0014-5793(99)01533-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Iron regulatory protein 2 (IRP2) is one of the central regulators of iron homeostasis. IRP2 regulates expression of molecules involved in iron metabolism by binding to iron responsive elements (IREs) in the transcripts of those molecules in iron depletion. IRP2 is regulated by the accelerated degradation initiated by the iron-catalyzed oxidation. Here we report that aluminum antagonizes the iron-induced decrease in IRE binding activity of IRP2. Aluminum also inhibits iron-induced oxidation of IRP2 in vitro. These results suggest that aluminum stabilizes IRP2 by interfering with the iron-catalyzed oxidation, which results in perturbation of iron metabolism.

【 授权许可】

Unknown