Cloning and characterization of Bδ, a novel regulatory subunit of protein phosphatase 2A

FEBS Letters

Strack, Stefan¹  Zaucha, Julie A.²  Chang, Dennis²  Wadzinski, Brian E.²  Colbran, Roger J.¹ 

[1] Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA;Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA

关键词: Phosphoprotein phosphatase;    Phosphorylation;    Signal transduction;    Protein phosphatase 2A;    Regulatory subunit;    Subcellular fraction;   

DOI  :  10.1016/S0014-5793(99)01377-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Variable regulatory subunits of protein phosphatase 2A (PP2A) modulate activity, substrate selectivity and subcellular targeting of the enzyme. We have cloned a novel member of the B type regulatory subunit family, Bδ, which is most highly related to Bα. Bδ shares with Bα epitopes previously used to generate subunit-specific antibodies. Like Bα, but unlike Bβ and Bγ which are highly brain-enriched, Bδ mRNA and protein expression in tissues is widespread. Bδ is a cytosolic subunit of PP2A with a subcellular localization different from Bα and may therefore target a pool of PP2A holoenzymes to specific substrates.

【 授权许可】

Unknown