The FHA domain

FEBS Letters

Jackson, Stephen P.²  Durocher, Daniel¹ 

[1] Samuel Lunenfeld Research Institute, Programme in Molecular Biology and Cancer, Mount Sinai Hospital, 600 University Ave., Toronto, ON, Canada M5G 1X5;Wellcome/CRC Institute of Cancer and Developmental Biology, Tennis Court Road, Cambridge CB2 1QR, UK

关键词: Phosphorylation;    Signal transduction;    Protein:protein interaction;    Kinase;    Forkhead-associated domain;    Kinesin;    Checkpoint;    DNA repair;   

DOI  :  10.1016/S0014-5793(01)03294-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The forkhead-associated (FHA) domain is a small protein module recently shown to recognize phosphothreonine epitopes on proteins. It is present in a diverse range of proteins in eukaryotic cells, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding proteins, and metabolic enzymes. It is also found in a number of bacterial proteins. This suggests that FHA domain-mediated phospho-dependent assembly of protein complexes is an ancient and widespread regulatory mechanism.

【 授权许可】

Unknown