Lipid signaling in CD95‐mediated apoptosis

FEBS Letters

Malisan, Florence¹  Testi, Roberto¹ 

[1] Department of Experimental Medicine and Biochemical Sciences, University of Rome ‘Tor Vergata’, via di Tor Vergata 135, 00133 Rome, Italy

关键词: Apoptosis;    CD95;    Sphingomyelinase;    Ceramide;    Disialoganglioside GD3;    Mitochondrion;   

DOI  :  10.1016/S0014-5793(99)00543-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Ceramides play an important role mediating different cell responses such as proliferation, differentiation, growth arrest and apoptosis. They are released upon sphingomyelin hydrolysis which occurs after triggering of a number of cell surface receptors including CD95. Ceramide generation also regulates glycosphingolipid and ganglioside metabolism. In particular, ganglioside GD3 biosynthesis represents an important event for the progression of apoptotic signals generated by CD95 and mediated by ceramide in hematopoietic cells.

【 授权许可】

Unknown