The diversity of the lipoxygenase family

FEBS Letters

Kuhn, Hartmut¹  Thiele, Bernd J¹ 

[1] Institute of Biochemistry, University Clinics (Charité), Humboldt University, Hessiche Str. 3-4, 10115 Berlin, Germany

关键词: Atherogenesis;    Inflammation;    Lipid peroxidation;    Cell development;    Eicosanoid;   

DOI  :  10.1016/S0014-5793(99)00396-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Lipoxygenases form a family of lipid peroxidising enzymes, which oxygenate free and esterified polyenoic fatty acids to the corresponding hydroperoxy derivatives. They are widely distributed in both the plant and animal kingdoms. During the last couple of years more and more lipoxygenase isoforms have been discovered but for most of them the biological significance remains unclear. This review attempts to classify the currently known mammalian lipoxygenase isoforms and critically reviews the concepts for their biological importance.

【 授权许可】

Unknown